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IdentificationBack Directory
[Synonyms]

PF-4800567 HCl
PF-4800567 hydrochloride >=98% (HPLC)
3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine:hydrochloride
[MDL Number]

MFCD20926348
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

Soluble to 100 mM in DMSO
[form ]

Powder
[color ]

white to beige
Hazard InformationBack Directory
[Biological Activity]

PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) th at is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocationbut does not effect the circadian clock in animal studies.''PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.
[storage]

Desiccate at RT
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