| Identification | Back Directory | [Name]
CAY10512 | [CAS]
139141-12-1 | [Synonyms]
CAY10512
1-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
Benzene, 1-fluoro-2-[(1E)-2-(4-methoxyphenyl)ethenyl]-
NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem | [Molecular Formula]
C15H13FO | [MDL Number]
MFCD12912333 | [MOL File]
139141-12-1.mol | [Molecular Weight]
228.262 |
| Chemical Properties | Back Directory | [Melting point ]
100-101 °C | [Boiling point ]
340.4±11.0 °C(Predicted) | [density ]
1.136±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 2 mg/ml; Ethanol: 0.5 mg/ml | [form ]
Crystalline solid | [color ]
White to off-white | [Cosmetics Ingredients Functions]
SKIN CONDITIONING - MISCELLANEOUS
ANTIOXIDANT | [InChIKey]
ILVFNAZMSMNXJG-RMKNXTFCSA-N | [SMILES]
Fc1c(cccc1)\C=C\c2ccc(cc2)OC |
| Hazard Information | Back Directory | [Uses]
CAY10512 is an inhibitor of NF-κB. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid, and can be used for research on Alzheimer's disease[1]. | [General Description]
A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM). | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C | [References]
[1] Alexandrov P N, et al. microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)[J]. International journal of biochemistry and molecular biology, 2012, 3(4): 365. |
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| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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