| Identification | Back Directory | [Name]
(5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one | [CAS]
139225-22-2 | [Synonyms]
(5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one
2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)- | [Molecular Formula]
C23H26N2O6 | [MDL Number]
MFCD00868699 | [MOL File]
139225-22-2.mol | [Molecular Weight]
426.46 |
| Chemical Properties | Back Directory | [Melting point ]
165 °C(Solv: ethanol (64-17-5); dichloromethane (75-09-2)) | [Boiling point ]
614.1±55.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (293.11 mM) | [form ]
Solid | [pka]
13.84±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1]. | [in vivo]
Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1]. | Animal Model: | Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g[1] | | Dosage: | 0.3, 1, 3, 30 mg/kg | | Administration: | Subcutanous injections | | Result: | Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. |
| [References]
[1] N Dahmen, et al. Induction of C-Fos Gene Expression by the Selective Sigma Receptor Ligand EMD 57445 in Rat Brain. Eur Neuropsychopharmacol. 1996 Aug;6(3):237-43. DOI:10.1016/0924-977x(96)00026-0 |
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