| Identification | Back Directory | [Name]
9H-Purine, 8-(1H-indol-4-yl)-6-[(3R)-3-methyl-4-morpholinyl]-2-[(3S)-3-methyl-4-morpholinyl]- | [CAS]
1392421-71-4 | [Synonyms]
PI3K/mTOR Inhibitor-9
9H-Purine, 8-(1H-indol-4-yl)-6-[(3R)-3-methyl-4-morpholinyl]-2-[(3S)-3-methyl-4-morpholinyl]- | [Molecular Formula]
C23H27N7O2 | [MOL File]
1392421-71-4.mol | [Molecular Weight]
433.51 |
| Hazard Information | Back Directory | [Uses]
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively[1]. | [IC 50]
mTOR: 16 nM (IC50, Ser240/244 cellular assay); mTOR: 38 nM (IC50, phospho-S6 cellular assay); PI3Kδ: 0.8 μM (IC50); PI3Kα: 6.6 μM (IC50); PI3Kγ: 6.6 μM (IC50); PI3Kβ: >10 μM (IC50) | [References]
[1] Bonazzi S, et al. Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders. J Med Chem. 2020 Feb 13;63(3):1068-1083. DOI:10.1021/acs.jmedchem.9b01398 |
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