| Identification | Back Directory | [Name]
N-DESMETHYL ZOLMITRIPTAN HCL | [CAS]
139264-35-0 | [Synonyms]
CAS:139264-35-0
ZolMitriptan USP RC A
N-Desmethyl Zolmitriptan
N-DESMETHYL ZOLMITRIPTAN HCL
ZolMitriptan Related CoMpound A
4-[[3-[2-(Methylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinon
4-[[3-[2-(Methylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinone
(4S)-4-[[3-[2-(MethylaMino)ethyl]-1H-indol-5-yl]Methyl-2-oxazolidinone
Zolmitriptan Related Compound A (20 mg) ((S)-4-({3-[2-(Methylamino)ethyl]-1H-indol-5-yl}methyl)oxazolidin-2-one) | [Molecular Formula]
C15H20ClN3O2 | [MDL Number]
MFCD08063714 | [MOL File]
139264-35-0.mol | [Molecular Weight]
309.79 |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Melting point ]
63-66°C | [Boiling point ]
577.7±35.0 °C(Predicted) | [density ]
1.235±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.57±0.40(Predicted) | [color ]
Light Yellow to Light Brown | [Stability:]
Hygroscopic | [CAS DataBase Reference]
139264-35-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
A metabolite of Zolmitriptan (Z639000). | [Description]
N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan . DZT is an agonist of 5-HT1B receptors that induces contraction of isolated human cerebral arteries (EC50 = 100 nM). | [storage]
Store at -20°C | [References]
[1] BHARGAV PATEL. Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: a sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study[J]. Biomedical Chromatography, 2015, 30 3: 447-458. DOI: 10.1002/bmc.3568
[2] TORUN NILSSON. Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry[J]. British Journal of Pharmacology, 2009, 128 6: 1133-1140. DOI: 10.1038/sj.bjp.0702773 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Finetech Industry Limited
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