| Identification | Back Directory | [Name]
SI-113 | [CAS]
1392816-46-4 | [Synonyms]
SI-113
SI113; SI-113; SI 113
Ethanol, 2-[[1-(2-phenylethenyl)-4-[(2-phenylethyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]- | [Molecular Formula]
C23H24N6O | [MDL Number]
MFCD33019772 | [MOL File]
1392816-46-4.mol | [Molecular Weight]
400.48 |
| Chemical Properties | Back Directory | [Boiling point ]
622.4±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml | [form ]
A solid | [pka]
14.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2]. | [References]
[1] Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. DOI:10.1016/j.bmcl.2012.07.014
[2] Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. DOI:10.1186/s13046-019-1212-1 |
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