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MHY884 is an tyrosinase inhibitor that acts by suppressing UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. | [Uses]
MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage[1]. | [References]
[1] Choi YJ, et al. MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1344-8. DOI:10.1016/j.bmcl.2014.01.040 |
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