| Identification | Back Directory | [Name]
TC LPA5 4 | [CAS]
1393814-38-4 | [Synonyms]
TC LPA5 4
BNALUYKEGYUHQC-UHFFFAOYSA-N
5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
1H-Pyrazole-3-carboxylic acid, 5-(3-chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)- | [Molecular Formula]
C23H23ClN2O3 | [MDL Number]
MFCD26792575 | [MOL File]
1393814-38-4.mol | [Molecular Weight]
410.89 |
| Chemical Properties | Back Directory | [Boiling point ]
600.4±55.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:41.09(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:8.22(Max Conc. mg/mL);20.0(Max Conc. mM) | [form ]
Solid | [pka]
3.75±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TC LPA5 4 is a LPA5 receptor antagonist. It inhibits LPA-induced aggregation of isolated human platelets and exhibits selectivity for LPA5 against 80 other screened targets. | [in vivo]
TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice[2]. | Animal Model: | BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) [2] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; 5 days/week for 2 weeks | | Result: | Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
|
| [storage]
Store at +4°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 19945035818 |
| Website: |
www.topule.com/ |
|