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139667-74-6

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139667-74-6 Structure

139667-74-6 Structure
IdentificationBack Directory
[Name]

CGP 52432
[CAS]

139667-74-6
[Synonyms]

P52432
CGP 52432
CGP52432 >=98% (HPLC)
CGP 52432;CGP-52432;CGP 52432
(3-((3,4-dichlorobenzyl)amino)propyl)(diethoxymethyl)phosphinic acid
3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID
Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-
[EINECS(EC#)]

-0
[Molecular Formula]

C15H24Cl2NO4P
[MDL Number]

MFCD02262128
[MOL File]

139667-74-6.mol
[Molecular Weight]

384.24
Chemical PropertiesBack Directory
[Boiling point ]

544.4±50.0 °C(Predicted)
[density ]

1.258±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble1mg/mL, clear (warmed)
[form ]

powder
[pka]

2.26±0.50(Predicted)
[color ]

white to beige
[Water Solubility ]

Soluble in water (10mM, gentle warming)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
  • to study its effects on the simulation of the onset of status epilepticus (SE) in mice
  • for voltage-clamp recording in mice neurons
  • to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus

[Definition]

ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.
[Biological Activity]

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).
[Biochem/physiol Actions]

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.
[storage]

+4°C (desiccate)
Spectrum DetailBack Directory
[Spectrum Detail]

CGP 52432(139667-74-6)1HNMR
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