| Hazard Information | Back Directory | [Description]
RO5464466 is an inhibitor of influenza A virus (H1N1) fusion. RO5464466 targeted HA. In cell-based assays involving multiple rounds of virus infection and replication, RO5464466 inhibited an established influenza infection. The overall production of progeny viruses, as a result of the compound's inhibitory effect on fusion, was dramatically reduced by 8 log units when compared with a negative control. Furthermore, RO5487624, a close analogue of | [Uses]
RO5464466 is an hemagglutinin (HA) inhibitor of influenza H1N1 viruses. RO5464466 inhibits HA-mediated hemolysis of chicken erythrocytes with the IC50 of 0.29 μM[1]. | [References]
[1] Zhu L, et al. Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin. PLoS One. 2011;6(12):e29120. DOI:10.1371/journal.pone.0029120 |
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