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1401-69-0

1401-69-0 Structure

1401-69-0 Structure
IdentificationBack Directory
[Name]

TYLOSIN
[CAS]

1401-69-0
[Synonyms]

Tylon
Vetil
TYLOSIN
TYLAN50
tylocine
Tylosine
Vetil(R)
Tylan 100
Tylosin A
fradizine
TYLOCINE(R)
Vubityl 200
N,N-Tylozine
Tylosin, 95+%
Tylosin (250 mg)
Tyrosine [antibiotic]
Tylosin solution,100ppm
DehydroreloMycin, Tylosin A
CAS: 1401-69-0 API Tylosin Drugs
Tylosin, predominantly Tylosin A
Tylosin solution solution,1000ppm
Tylosin (base and/or unspecified salts)
Tylosin (predominantly Tylosin A) Solution, 100ppm
[EINECS(EC#)]

215-754-8
[Molecular Formula]

C46H77NO17
[MDL Number]

MFCD00056845
[Molecular Weight]

916.1
[MOL File]

1401-69-0.mol
Chemical PropertiesBack Directory
[Melting point ]

135-137°C
[Boiling point ]

796.05°C (rough estimate)
[alpha ]

D25 -46° (c = 2 in methanol)
[density ]

1.1424 (rough estimate)
[refractive index ]

1.5280 (estimate)
[storage temp. ]

2-8°C
[pka]

pKa 7.73(H2O t = 25 I = 0.167) (Uncertain)
[Water Solubility ]

H2O: soluble 50 mg/mL
[Stability:]

Solutions are stable at pH 4-9 (most stable at pH 7);
Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;
In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;
When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed.
[Contact allergens]

Tylosin is a macrolid antibiotic used in veterinary medicine. Occupational exposure concerns farmers, breeders, animal feed workers, and veterinarians.
[EPA Substance Registry System]

Tylosin(1401-69-0)
Hazard InformationBack Directory
[Chemical Properties]

Off-White to Pale Yellow Solid
[Uses]

paramagnetic agent
[Uses]

Macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.
[Uses]

Tylosin is a 16-membered macrocyclic lactone isolated from Streptomyces fradiae in 1961. Tylosin has broad spectrum antibacterial activity and was developed as a veterinary pharmaceutical for treatment of bacterial infections in a range of domestic animals . Tylosin acts by binding to the 50S ribosomal subunit resulting in the inhibition of protein synthesis in bacteria.
[Definition]

ChEBI: A macrolide antibiotic that is tylonolide having monoand diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae.
[Description]

Occupational exposure concerns farmers, breeders, animal-feed workers and veterinarians.
[Indications]

In cattle, tylosin is used for treatment of BRD caused by Mannheimia, Pasteurella multocida, and Histophilus somni (formerly Haemophilus somnus). It is used for interdigital necrobacillosis (foot rot) in cattle caused by Fusobacterium necrophorum or Bacteroides melaninogenicus. In pigs, it is used for treatment of swine arthritis caused by Mycoplasma hyosynoviae, swine pneumonia caused by Pasteurella spp., swine erysipelas caused by Erysipelothrix rhusiopathiae, swine dysentery associated with Serpulina (Treponema) hyodysenteriae, and proliferative enteropathy caused by L. intracellularis. For treatment in pigs, it is also added to feed (Type A–medicated feed article) or drinking water. In small animals, it is used for gram-positive soft tissue and skin infections. However, the most common use in dogs is for treatment of diarrhea, referred to as antibiotic-responsive diarrhea, that has not responded to other treatments. The etiology of the diarrhea is not known but may be caused by Clostridium or Camphylobacter. For this use, the powdered formulation (swine formulation) is most often added to food daily for maintenance.
[Brand name]

Tylan (Lilly).
[Mechanism of action]

Tylosin is a 16-membered macrolide approved for therapy of a variety of infections in pigs, cattle, dogs, and poultry (see indications below). It is formulated as tylosin tartrate or tylosin phosphate. Like other macrolide antibiotics, tylosin inhibits bacteria by binding to the 50S ribosome and inhibiting protein synthesis. Spectrum of activity is limited primarily to gram-positive aerobic bacteria. Clostridium and Campylobacter are usually sensitive. The spectrum also includes the bacteria that cause BRD. Escherichia coli and Salmonella are resistant. In pigs, Lawsonia intracellularis is sensitive.
[Side effects]

Tylosin may cause diarrhea in some animals. However, oral treatment for colitis in dogs has been administered for several months with safety. Skin reactions have been observed in pigs. Oral administration to horses has been fatal.
[Veterinary Drugs and Treatments]

Although the injectable form of tylosin is approved for use in dogs and cats, it is rarely used parenterally in those species. Oral tylosin is sometimes recommended for the treatment of chronic colitis in small animals (see Doses), but controlled studies documenting its efficacy have not been performed.
Tylosin is also used clinically in cattle and swine for infections caused by susceptible organisms.
[Solubility in organics]

soluble in lower alcohols, esters, ketones,chlorinated hydrocarbons, benzene, ether, chloroform.
Safety DataBack Directory
[Hazard Codes ]

Xn,N
[Risk Statements ]

42/43-50
[Safety Statements ]

36-61-45-36/37-22
[HS Code ]

2941906000
[Safety Profile]

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also TnOSIN HYDROCHLORIDE.
[Hazardous Substances Data]

1401-69-0(Hazardous Substances Data)
[Toxicity]

Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.
Raw materials And Preparation ProductsBack Directory
【Preparation Products】

Cefepime hydrochloride-->Tilmicosin phosphate
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