| Identification | Back Directory | [Name]
Oleic Acid-2,6-diisopropylanilide | [CAS]
140112-65-8 | [Synonyms]
Reaxys ID: 5829364
(Z)-N-[2,6-di(propan-2-yl)phenyl]octadec-9-enamide | [Molecular Formula]
C30H51NO | [MDL Number]
MFCD08059579 | [MOL File]
140112-65-8.mol | [Molecular Weight]
441.73 |
| Chemical Properties | Back Directory | [Boiling point ]
557.7±49.0 °C(Predicted) | [density ]
0.919±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
14.98±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%. | [Uses]
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%. | [storage]
Store at -20°C | [References]
1. Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism J. Lipid Res. 26(6),647-671(1985).
2. Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents J. Med. Chem. 35(9),1609-1617(1992). |
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