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1402452-10-1

1402452-10-1 Structure

1402452-10-1 Structure
IdentificationBack Directory
[Name]

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
[CAS]

1402452-10-1
[Synonyms]

hSMG-1 inhibitor 11e
Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
[Molecular Formula]

C26H27N7O3S
[MOL File]

1402452-10-1.mol
[Molecular Weight]

517.6
Chemical PropertiesBack Directory
[storage temp. ]

4°C, away from moisture and light
[solubility ]

DMSO : 50 mg/mL (96.60 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1].
[Biological Activity]

HSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with IC50 value <0.05 nM. hSMG-1 inhibitor 11e exhibits 900-fold selectivity for hSMG-1 over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50 of 61 nM and 92 nM) and CDK1/CDK2 (IC50 of 32 μM and 7.1 μM).
[in vitro]

HSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment.

[target]

mTOR

45 nM (IC 50 )

PI3Kα

61 nM (IC 50 )

PI3Kγ

92 nM (IC 50 )

CDK1

32 μM ( IC 50 )

CDK2

7.1 μM (IC 50 )

hSMG-1

<0.05 nM (IC 50 )

[IC 50]

hSMG-1: <0.05 nM (IC50); mTOR: 45 nM (IC50); PI3Kα: 61 nM (IC50); PI3Kγ: 92 nM (IC50); CDK1: 32 μM (IC50); CDK2: 7.1 μM (IC50)
[storage]

4°C, away from moisture and light
[References]

[1] Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41. DOI:10.1016/j.bmcl.2012.08.107
Spectrum DetailBack Directory
[Spectrum Detail]

Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-(1402452-10-1)1HNMR
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