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1402931-84-3

1402931-84-3 Structure

1402931-84-3 Structure
IdentificationBack Directory
[Name]

1H-Cyclopenta[b]benzofuran-2-carboxamide, 6-cyano-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-
[CAS]

1402931-84-3
[Synonyms]

eIF4A3-IN-18
1H-Cyclopenta[b]benzofuran-2-carboxamide, 6-cyano-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-
[Molecular Formula]

C29H28N2O6
[MOL File]

1402931-84-3.mol
[Molecular Weight]

500.54
Chemical PropertiesBack Directory
[Boiling point ]

671.1±55.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

11.45±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].
[References]

[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542
1402931-84-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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