| Identification | Back Directory | [Name]
1H-Cyclopenta[b]benzofuran-2-carboxamide, 6-cyano-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- | [CAS]
1402931-84-3 | [Synonyms]
eIF4A3-IN-18 1H-Cyclopenta[b]benzofuran-2-carboxamide, 6-cyano-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- | [Molecular Formula]
C29H28N2O6 | [MOL File]
1402931-84-3.mol | [Molecular Weight]
500.54 |
| Chemical Properties | Back Directory | [Boiling point ]
671.1±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.45±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1]. | [References]
[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542 |
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