| Hazard Information | Back Directory | [Description]
GSK729 is a novel potent inhibitor of EchA6. | [Uses]
GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model. | [References]
[1] THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria DOI:10.1038/nmicrobiol.2015.6 |
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