Identification | Back Directory | [Name]
LAS191954 | [CAS]
1403947-26-1 | [Synonyms]
LAS191954 LAS191954,LAS-191954 (S)-2-(1-((6-AMINO-5-CYANOPYRIMIDIN-4-YL)AMINO)ETHYL)-4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZINE-5-CARBONITRILE | [Molecular Formula]
C20H15N9O | [MDL Number]
MFCD28502110 | [MOL File]
1403947-26-1.mol | [Molecular Weight]
397.39 |
Chemical Properties | Back Directory | [Boiling point ]
769.0±70.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
2.71±0.10(Predicted) |
Hazard Information | Back Directory | [Uses]
LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1]. | [IC 50]
PI3Kδ: 2.6 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Erra M, et al. Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123. DOI:10.1021/acsmedchemlett.6b00438 |
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Company Name: |
AstaTech, Inc
|
Tel: |
(215) 785 3197 |
Website: |
www.astatechinc.com |
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