ChemicalBook--->CAS DataBase List--->1403947-26-1

1403947-26-1

1403947-26-1 Structure

1403947-26-1 Structure
IdentificationBack Directory
[Name]

LAS191954
[CAS]

1403947-26-1
[Synonyms]

LAS191954
LAS191954,LAS-191954
(S)-2-(1-((6-AMINO-5-CYANOPYRIMIDIN-4-YL)AMINO)ETHYL)-4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZINE-5-CARBONITRILE
[Molecular Formula]

C20H15N9O
[MDL Number]

MFCD28502110
[MOL File]

1403947-26-1.mol
[Molecular Weight]

397.39
Chemical PropertiesBack Directory
[Boiling point ]

769.0±70.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

2.71±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM[1].
[IC 50]

PI3Kδ: 2.6 nM (IC50)
[storage]

Store at -20°C
[References]

[1] Erra M, et al. Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123. DOI:10.1021/acsmedchemlett.6b00438
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