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1404463-20-2

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1404463-20-2 Structure

1404463-20-2 Structure
IdentificationBack Directory
[Name]

2'-ara-2'-F-2'-dG Phosphoramidite
[CAS]

1404463-20-2
[Synonyms]

2'-ara-2'-F-2'-dG Phosphoramidite
2'-F-2'-ara-ibu-dG Phosphoramidite
2'-F-dG(iBu)-ANA-CE Phosphoramidite
2'-F-2'-ara-N2-ibu-dG phosphoramidite
9-[2-FLUORO-2-DEOXY-5-O-DMTr-B-D- ARABINOFURANOSYL]-N2-ISOBUTYRYL- GUANINE-3-O-CE-AMIDITE
5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite
5'-O-DMT-2'-Fluoro-N2-isobutyryl-2'-arabinofuranosyl-2'-deoxyguanosine 3'-CE phosphoramidite
N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite
Propanamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-
[Molecular Formula]

C44H53FN7O8P
[MDL Number]

MFCD15145400
[MOL File]

1404463-20-2.mol
[Molecular Weight]

857.92
Chemical PropertiesBack Directory
[solubility ]

DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
[pka]

8.68±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

9-(2''-Deoxy-5''-O-DMT-2''-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3''-CE phosphoramidite is a reagent used in the preparation of siRNA nanocarries that are based on methacrylic acid copolymers.
[References]

[1] ARNAUD E. FELBER . The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity[J]. Biomaterials, 2012, 33 25: Pages 5955-5965. DOI: 10.1016/j.biomaterials.2012.05.019
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