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140712-83-0

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140712-83-0 Structure

140712-83-0 Structure
IdentificationBack Directory
[Name]

(N4-BENZOYL)-5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE
[CAS]

140712-83-0
[Synonyms]

DMT-dC(Bz)-CE Reverse Phosphoramidite
DMT-dC(Bz)-5'-CE Reverse Phosphoramidite
N4-Bz-3’-O-DMTr-2’-deoxycytidine 5’-O-CE-phosphoramidite
N4-Benzoyl-2'-deoxy-3'-O-DMT-cytidine 5'-CE phosphoramidite
N4-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-5'-cyanoethyl Phosphoramidite
(N4-Benzoyl)-5'-O-[(N,N-diisopropylamino)(2-cyanoethoxy)phoshinyl}-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
N-Benzoyl-5'-O-[(diisopropylaMino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-diMethoxytrityl)-2'-deoxycytidine, 97%
(N4-BENZOYL)-5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE
(N4-BENZOYL)-5''-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3''-O-(4,4''-DIMETHOXYTRITYL)-2''-DEOXYCYTIDINE
Cytidine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Cytidine,N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethylbis(1-methylethyl)phosphoramidite] (9CI)
[Molecular Formula]

C46H52N5O9P
[MDL Number]

MFCD04972286
[MOL File]

140712-83-0.mol
[Molecular Weight]

849.91
Chemical PropertiesBack Directory
[pka]

8.66±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312a-P330-P501a
Hazard InformationBack Directory
[Uses]

Rev dC(Bz)-5'-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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