| Identification | Back Directory | [Name]
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE | [CAS]
140873-26-3 | [Synonyms]
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE
Benzamide, 4-amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]- | [Molecular Formula]
C26H35N7O2 | [MDL Number]
MFCD09971018 | [MOL File]
140873-26-3.mol | [Molecular Weight]
477.6 |
| Hazard Information | Back Directory | [Uses]
Aminopotentidine is a histamine H2 receptor antagonist with KB values of 220 nM and 280 nM for human and guinea pig H2 receptors, respectively. It can also serve as a precursor for the synthesis of [125I] iodo derivatives[1]. | [Definition]
ChEBI: Aminopotentidine is a benzamide obtained by formal condensation of the carboxy group of 4-aminobenzoic acid with the primary amino group of 1-(2-aminoethyl)-2-cyano-3-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}guanidine. It has a role as a H2-receptor antagonist. It is a member of guanidines, a member of benzamides, a substituted aniline, a nitrile, an aromatic ether and a member of piperidines. | [Biological Activity]
H 2 antagonist (K B values are 220 and 280 nM at human and guinea pig H 2 receptors respectively) and precursor for the synthesis of the [ 125 I]-iodo derivative. | [IC 50]
H2 Receptor: 220 nM (Kb) | [storage]
Store at -20°C | [References]
[1] Hirschfeld J, et al. Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor[J]. Journal of medicinal chemistry, 1992, 35(12): 2231-2238. DOI:10.1021/jm00090a013 |
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