| Identification | Back Directory | [Name]
D-gamma-Tocotrienol | [CAS]
14101-61-2 | [Synonyms]
D-G-TOCOTRIENOL
Gama-Tocotrienol
D-GAMMA-TOCOTRIENOL
(R)-gamma-Tocotrienol
7,8-Dimethyltocotrienol
6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (7ci,8ci)
(R-(E,E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
(R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [R-(E,E)]-
(2R)-2β,7,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-3,4-dihydro-2H-1-benzopyran-6-ol
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2R)-
2H-1-Benzopyran-6-ol,3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-,(2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-tr imethyl-3,7,11-tridecatrienyl]-, (2R)- (9CI)
(R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol | [Molecular Formula]
C28H42O2 | [MDL Number]
MFCD05864856 | [MOL File]
14101-61-2.mol | [Molecular Weight]
410.63 |
| Chemical Properties | Back Directory | [Boiling point ]
530.8±49.0 °C(Predicted) | [density ]
0.964±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
11.05±0.40(Predicted) | [color ]
Very Dark Yellow Thick | [biological source]
Elaeis guineensis | [Stability:]
Light Sensitive | [Major Application]
pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products | [InChIKey]
OTXNTMVVOOBZCV-WAZJVIJMSA-N | [SMILES]
[C@@]1(C)(CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C)OC2=C(C)C(C)=C(O)C=C2CC1 | [LogP]
10.300 (est) |
| Hazard Information | Back Directory | [Description]
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.1,2 It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 μM.2 γ-Tocotrienol (20 μM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.3 In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.4 [Matreya, LLC. Catalog No. 2111] | [Chemical Properties]
g:d:aTocotrienol 1.6:0.4:1 | [Uses]
γ-Tocotrienol exhibits antioxidant properties and belongs to the vitamin E family. It is naturally found in wheat germ oil and bran. In addition, α-tocopherol and γ-tocotrienol derivatives are potential lead compounds for developing?anticancer and?antiproliferative agents against?MCF-7 and MDA-MB-231 breast cancer cells and the A549 lung cancer cells. | [Definition]
ChEBI: A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. | [in vivo]
γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i.v.; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice[3].
GT3-Nano (50 mg/kg; i.v.; ) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP[3].
| Animal Model: | C57/BL6 mice (6-8 weeks old) treated with the whole-body irradiation[3] | | Dosage: | 16, 24, 32, and 50 mg/kg | | Administration: | Intravenous injection; observed mice for 100 days | | Result: | Demonstrated dose-dependent radioprotection, achieving 90% survival at 50 mg/kg against lethal 9-Gy of total-body irradiation (TBI).
And upregulated progenitor bone marrow cells MPP2 and CMP in GT3-Nano-treated mice. |
| [References]
[1] AFAF KAMAL-ELDIN Lars ? A. The chemistry and antioxidant properties of tocopherols and tocotrienols[J]. Lipids, 1996, 31 7: 671-701. DOI: 10.1007/bf02522884
[2] FUMITAKA OSAKADA . α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons[J]. Neuropharmacology, 2004, 47 6: Pages 904-915. DOI: 10.1016/j.neuropharm.2004.06.029
[3] SUMIT SHAH Paul W S. Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells.[J]. Experimental Biology and Medicine, 2004, 229 8: 745-755. DOI: 10.1177/153537020422900806
[4] M A NEWAZ. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol.[J]. Journal of Physiology and Pharmacology, 2003, 54 3: 319-327.
[5] MATTHEW J. KUHN Lorraine M S. Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes[J]. Journal of Animal Physiology and Animal Nutrition, 2021, 106 1: 55-60. DOI: 10.1111/jpn.13547
[6] M.J. KUHN L. M S. Vitamin E analogs limit in vitro oxidant damage to bovine mammary endothelial cells[J]. Journal of Dairy Science, 2021, 104 6: Pages 7154-7167. DOI: 10.3168/jds.2020-19675 |
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| Company Name: |
cjbscvictory Gold
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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