| Identification | Back Directory | [Name]
MDM2-IN-1 | [CAS]
1410737-09-5 | [Synonyms]
MDM2-IN-1
MDM2IN1,MDM2 IN 1,MDM-2-IN-1
Dispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indole]-5'-carboxylic acid, 6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'',2''-dihydro-2''-oxo-, (3'R,4'S,5'R)- | [Molecular Formula]
C23H21Cl2FN2O3 | [MDL Number]
MFCD33402161 | [MOL File]
1410737-09-5.mol | [Molecular Weight]
463.33 |
| Chemical Properties | Back Directory | [Boiling point ]
648.0±55.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 22.5 mg/mL (48.56 mM; Need ultrasonic) | [form ]
Solid | [pka]
1.82±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
MDM2-IN-1 (Compound 30) is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration[1]. | [storage]
4°C, protect from light | [References]
[1] Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98. DOI:10.1021/jm501541j |
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