| Identification | Back Directory | [Name]
E 7010 | [CAS]
141430-65-1 | [Synonyms]
E 7010
CS-505
CS-1806
ABT-751 (E
E7010(ABT-751)
ABT-751 (E7010)
E 7010 ISO 9001：2015 REACH
ABT-751 (E7010);ABT751; ABT 751
ABT751; ABT 751; E7010; E-7010; E 7010
N-[2-(4-HYDROXYANILINO)PYRIDIN-3-YL]-4-METHOXYBENZENE-1-SULFONAMIDE
N-[2-[(4-Hydroxyphenyl)amino]-3-pyridyl]-4-methoxybenzenesulfonamide
N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide
N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
BenzenesulfonaMide, N-[2-[(4-hydroxyphenyl)aMino]-3-pyridinyl]-4-Methoxy- | [EINECS(EC#)]
256-495-9 | [Molecular Formula]
C18H17N3O4S | [MDL Number]
MFCD00910291 | [MOL File]
141430-65-1.mol | [Molecular Weight]
371.41 |
| Chemical Properties | Back Directory | [Melting point ]
162 °C(dec.) | [Boiling point ]
551.0±60.0 °C(Predicted) | [density ]
1.427 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic | [form ]
powder to crystal | [pka]
7.86±0.40(Predicted) | [color ]
White to Yellow to Orange |
| Hazard Information | Back Directory | [Description]
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM).1 It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models.2 It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.3 | [Definition]
ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide. |
|
|