| Identification | Back Directory | [Name]
3-Phenylpiperidine-2,6-dione | [CAS]
14149-34-9 | [Synonyms]
3-Phenyl-2,6-piperidinedione
3-Phenylpiperidine-2,6-dione
2,6-Piperidinedione, 3-phenyl- | [Molecular Formula]
C11H11NO2 | [MOL File]
14149-34-9.mol | [Molecular Weight]
189.21 |
| Chemical Properties | Back Directory | [Melting point ]
143-144 °C | [Boiling point ]
392.3±31.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [pka]
11.32±0.40(Predicted) | [InChI]
InChI=1S/C11H11NO2/c13-10-7-6-9(11(14)12-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13,14) | [InChIKey]
KAKZYGLQCHMNGS-UHFFFAOYSA-N | [SMILES]
N1C(=O)CCC(C2=CC=CC=C2)C1=O |
| Hazard Information | Back Directory | [Uses]
E3 ligase Ligand PG is a E3 ligase ligand that can be used in the recruitment of CRBN protein. E3 ligase Ligand PG exhibits potent binding activity with CRBN (IC50 of 2.191 μM). E3 ligase Ligand PG can be connected to the BMS-202 (HY-19745) by a linker to form PROTAC, PROTAC PD-L1 degrader-1 (HY-163757)[1]. | [IC 50]
Cereblon: 2.191 μM (IC50) | [References]
[1] Hongjia Zhang, et al. Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem. 2024 Jun 18. DOI:10.1021/acs.jmedchem.3c02259 |
|
|