| Identification | Back Directory | [Name]
Urea, N-[4-[8-aMino-3-(1-Methylethyl)iMidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoroMethyl)phenyl]- | [CAS]
1414938-21-8 | [Synonyms]
IRE1α-IN-3
IRE1α kinase-IN-2
1-[4-(8-amino-3-propan-2-ylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
Urea, N-[4-[8-aMino-3-(1-Methylethyl)iMidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoroMethyl)phenyl]- | [Molecular Formula]
C27H23F3N6O | [MDL Number]
MFCD28386485 | [MOL File]
1414938-21-8.mol | [Molecular Weight]
504.51 |
| Hazard Information | Back Directory | [Uses]
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1]. | [Biological Activity]
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].
IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1]. | [storage]
Store at -20°C | [References]
[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989. |
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| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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