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1415246-68-2

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1415246-68-2 Structure

1415246-68-2 Structure
IdentificationBack Directory
[Name]

MMAF (Hydrochloride)
[CAS]

1415246-68-2
[Synonyms]

CS-1270
MMAF HCl
MMAF (Hydrochloride)
Monomethylauristatin F Hydrochloride
[Molecular Formula]

C39H66ClN5O8
[MOL File]

1415246-68-2.mol
[Molecular Weight]

768.423
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C,unstable in solution, ready to use.
[solubility ]

DMSO: 27 mg/mL (35.14 mM and warming)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MMAF Hydrochloride can be used as reactant/reagent for antibody-drug conjugates.
[in vivo]

The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively[4].

[IC 50]

Auristatin
[storage]

Store at -20°C,unstable in solution, ready to use.
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