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1416324-85-0

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1416324-85-0 Structure

1416324-85-0 Structure
IdentificationBack Directory
[Name]

5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester
[CAS]

1416324-85-0
[Synonyms]

CU-CPT22
CU-CPT22 >=98% (HPLC)
hexyl 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate
inhibit,CU CPT22,Inhibitor,CU-CPT22,Toll-like Receptor (TLR),CUCPT22,CU-CPT-22
3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester
[Molecular Formula]

C19H22O7
[MDL Number]

MFCD26406409
[MOL File]

1416324-85-0.mol
[Molecular Weight]

362.37
Chemical PropertiesBack Directory
[Boiling point ]

610.4±55.0 °C(Predicted)
[density ]

1.336±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

Powder
[pka]

6.04±0.20(Predicted)
[color ]

orange to dark red
Safety DataBack Directory
[Hazard Codes ]

N
[Risk Statements ]

50/53
[Safety Statements ]

60-61
[RIDADR ]

UN 3077 9 / PGIII
Hazard InformationBack Directory
[Description]

CU CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2; Ki = 0.41 μM). It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam3CSK4 in RAW 264.7 cells (IC50 = 0.58 μM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 μM. CU CPT 22 (8 μM) inhibits Pam3CSK4-induced release of TNF-α and IL-1β in RAW 264.7 cells by 60 and 95%, respectively.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester(1416324-85-0)1HNMR
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