ChemicalBook--->CAS DataBase List--->1416435-96-5

1416435-96-5

1416435-96-5 Structure

1416435-96-5 Structure
IdentificationBack Directory
[Name]

GB-88
[CAS]

1416435-96-5
[Synonyms]

GB-88
Spiro[1H-indene-1,4'-piperidine], 1'-[3-cyclohexyl-N-(5-isoxazolylcarbonyl)-L-alanyl-L-isoleucyl]-
[Molecular Formula]

C32H42N4O4
[MDL Number]

MFCD29920338
[MOL File]

1416435-96-5.mol
[Molecular Weight]

546.7
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 31.25 mg/mL (57.16 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM[1].
[in vivo]

GB-88 (10 mg/kg, p.o. in olive oil) is both orally active and anti-inflammatory in vivo, with specific antagonist activity against four structurally and mechanistically different PAR2 agonists (2f-LIGRLO-NH2, trypsin, SLIGRL-NH2 and GB110)[1].
GB-88 inhibits PAR2-induced acute inflammation in vivo[1].

Animal Model:Male Wistar rats (8–9 weeks)[1]
Dosage:10 mg/kg
Administration:Oral gavage in olive oil
Result:Was both orally active and anti-inflammatory in vivo, with specific antagonist activity against four structurally and mechanistically different PAR2 agonists (2f-LIGRLO-NH2, trypsin, SLIGRL-NH2 and GB110).
[IC 50]

PAR2: 2 μM (IC50)
[References]

[1] Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23. DOI:10.1111/j.1476-5381.2011.01610.x
1416435-96-5 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Website: https://www.targetmol.com/
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Tel: 010-50973130 18101056239
Website: www.solarbio.com
Company Name: Shanghai Anyinuo Biomedical Technology Co., Ltd.  
Tel: 021-34625901 18018851262;
Website: https://www.aynchem.com
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Website: www.bio-fount.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Website: www.chemicalbook.com/ShowSupplierProductsList873228/0_EN.htm
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Shanghai Zunlijia Life Technology Co., Ltd  
Tel: 021-34045219 13062664914
Website: www.zunlijia.com
Company Name: Changzhou Yourui Pharmaceutical Technology Co., Ltd  
Tel: 18168818882
Website:
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Website: www.biosynth.com
Company Name: Adooq Bioscience LLC  
Tel: 400-025-6535
Website: http://www.adooq.cn
Company Name: Hebei Yaocheng Pharmaceutical Technology Co. Ltd  
Tel: 18033875090
Website: www.yaochengph.com
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Website: www.zzsrm.com
Company Name: Guangzhou Jingyan Biotechnology Co., Ltd.  
Tel: 13822277471
Website: www.chemicalbook.com/ShowSupplierProductsList1260513/0_EN.htm
Tags:1416435-96-5 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.