| Identification | Back Directory | [Name]
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione | [CAS]
1416990-08-3 | [Synonyms]
Lenalidomide-OH
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(5-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
3-(1,3-Dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
2,6-Piperidinedione, 3-(1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)- | [Molecular Formula]
C13H12N2O4 | [MDL Number]
MFCD31794971 | [MOL File]
1416990-08-3.mol | [Molecular Weight]
260.25 |
| Chemical Properties | Back Directory | [Boiling point ]
631.5±55.0 °C(Predicted) | [density ]
1.498±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.32±0.20(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1]. | [IC 50]
Cereblon | [References]
[1] Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. DOI:10.1016/j.bmcl.2019.126877 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 18918157536; |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
|