ChemicalBook--->CAS DataBase List--->1417302-71-6

1417302-71-6

1417302-71-6 Structure

1417302-71-6 Structure
IdentificationBack Directory
[Name]

L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl-
[CAS]

1417302-71-6
[Synonyms]

GLP-1(32-36)amide
L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl-
[Molecular Formula]

C25H50N10O5
[MDL Number]

MFCD33023596
[MOL File]

1417302-71-6.mol
[Molecular Weight]

570.73
Chemical PropertiesBack Directory
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 250 mg/mL (438.04 mM)
[form ]

Solid
[pka]

13.30±0.46(Predicted)
[color ]

White to off-white
[Sequence]

Leu-Val-Lys-Gly-Arg-NH2
Hazard InformationBack Directory
[Uses]

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2].
[in vivo]

GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice[2].
GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice[2].
GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice[3].

Animal Model:Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2]
Dosage:1 μmol/kg
Administration:I.p. once daily for 21 days
Result:Signi?cantly lowered the cumulative values of food and water intake.
Lowered fasting glucose.
Reduced the level of Hemoglobin A1c (HbA1c).
Improved glucose tolerance.
Suppressed body weight gain.
[References]

[1] Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4. DOI:10.1016/j.peptides.2014.06.004
[2] Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90. DOI:10.1111/cbdd.12615
[3] Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19. DOI:10.2337/db14-1708
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