| Identification | Back Directory | [Name]
3-Phenylisothiazol-5-amine | [CAS]
14208-52-7 | [Synonyms]
3-Phenylisothiazol-5-amine
3-phenyl-1,2-thiazol-5-aMine
5-Isothiazolamine, 3-phenyl-
3-Phenyl-isothiazol-5-ylamine | [Molecular Formula]
C9H8N2S | [MDL Number]
MFCD07382685 | [MOL File]
14208-52-7.mol | [Molecular Weight]
176.24 |
| Chemical Properties | Back Directory | [Melting point ]
163 °C | [Boiling point ]
269.8±38.0 °C(Predicted) | [density ]
1.261±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
6.88±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
In a sealed tube, (Z)-3-amino-3-phenylacrylonitrile (95 mg, 0.660 mmol) was dissolved in a solvent mixture of EtOH (1.0 mL) and THF (1.0 mL). H2S gas was bubbled into the solution for 5 min. Subsequently, the reaction mixture was stirred at 90 °C for 20 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure. The concentrated residue was dissolved in MeOH (2.0 mL) and H2O2 (30%, 0.5 mL) was added. The reaction was terminated by stirring at room temperature for 2 min. The mixture was again concentrated under reduced pressure. Finally, the residue was purified by high performance liquid chromatography (HPLC) to afford the target product 3-phenylisothiazol-5-amine (22 mg). | [References]
[1] Patent: US2013/131040, 2013, A1. Location in patent: Paragraph 1140 |
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| Company Name: |
China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
Wuxi AppTec
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022-59987777 13552403979 |
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www.labnetwork.com |
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Cool Pharm, Ltd
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021-58581007 18019463053 |
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http://www.coolpharm.com.cn |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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