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1421-14-3

1421-14-3 Structure

1421-14-3 Structure
IdentificationBack Directory
[Name]

propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
[CAS]

1421-14-3
[Synonyms]

Epontol
TH-2180
WH-5668
FBA-1420
BAY-1420
Fabantol
Fabontal
Sombrevin
propanidid
Bayer-1420
PROPANIDIDE
KEJXLQUPYHWCNM-UHFFFAOYSA-N
propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate USP/EP/BP
propyl 2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetate
propyl 2-[4-[2-(diethylamino)-2-oxo-ethoxy]-3-methoxy-phenyl]ethanoate
Benzeneacetic acid, 4-[2-(diethylamino)-2-oxoethoxy]-3-methoxy-, propyl ester
2-[4-[2-(diethylamino)-2-keto-ethoxy]-3-methoxy-phenyl]acetic acid propyl ester
[EINECS(EC#)]

215-822-7
[Molecular Formula]

C18H27NO5
[MOL File]

1421-14-3.mol
[Molecular Weight]

337.41
Chemical PropertiesBack Directory
[Boiling point ]

bp0.7 210-212°
[density ]

1.2043 (rough estimate)
[refractive index ]

1.5000 (estimate)
[storage temp. ]

Refrigerator
[solubility ]

DMSO (Slightly), Ethyl Acetate (Slightly)
[form ]

Oil
[color ]

Pale Yellow to Yellow
[EPA Substance Registry System]

Propanidid (1421-14-3)
Hazard InformationBack Directory
[Chemical Properties]

yellow oil bp0.7 210-212°C soluble in alcohol, chloroform, essentially water insoluble anasthetic Epontol (Bayer) Sombrevin
[Uses]

Anesthetic (intravenous).
[Uses]

Sombrevin, is an ultra short-acting phenylacetate general anesthetic.
[Definition]

ChEBI: Propanidid is a member of methoxybenzenes.
[Brand name]

Epontol (Farbenfabriken Bayer A.G., Germany).
[Clinical Use]

Propanidid is used as a very short- to shortacting intravenous anesthetic for minor surgery and gynecology. It is characterized by rapid onset of and quick recovery from anesthesia, producing surgical anesthesia for 3 – 4 min. Repeated injections can be used to prolong the anesthesia. Postanesthetic sleep does not occur because the propyl ester is hydrolyzed rapidly in the patient to form inactive 3-methoxy-4- (N,N-diethylcarbamoylmethoxy)phenylacetic acid. After 20 – 30 min the patients generally are completely responsive .
[Synthesis]

Propanidid , propyl 3- methoxy-4-(N,N-diethylcarbamoylmethoxy)- phenylacetate, is a colorless to pale yellowish water-insoluble oil. It is prepared from the propyl ester of sodium homovanillic acid and N,N-diethylchloroacetamide .
Synthesis_1421-14-3
Safety DataBack Directory
[Toxicity]

LD50 orally in rats: >10,000 mg/kg (Goldenthal)
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