| Identification | Back Directory | [Name]
fg-4592 int 2 | [CAS]
1421312-34-6 | [Synonyms]
Fg6347
ROXA-019
fg-4592 int 2
Fg-4592/FG4592 int 2
Roxadustat Impurity 34
Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate
methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid
1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate
3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester
methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate | [Molecular Formula]
C18H15NO4 | [MDL Number]
MFCD30489347 | [MOL File]
1421312-34-6.mol | [Molecular Weight]
309.32 |
| Chemical Properties | Back Directory | [Boiling point ]
537.3±45.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere, 2-8°C | [pka]
6.24±0.50(Predicted) | [InChI]
InChI=1S/C18H15NO4/c1-11-15-10-13(23-12-6-4-3-5-7-12)8-9-14(15)17(20)16(19-11)18(21)22-2/h3-10,20H,1-2H3 | [InChIKey]
WJGPMRFWBJZJOQ-UHFFFAOYSA-N | [SMILES]
C1(C)C2=C(C=CC(OC3=CC=CC=C3)=C2)C(O)=C(C(OC)=O)N=1 |
| Hazard Information | Back Directory | [Uses]
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency. | [Preparation]
Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%). |
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