| Identification | Back Directory | [Name]
Hederacoside C | [CAS]
14216-03-6 | [Synonyms]
Hederacol
Aids086294
Aids-086294
Tauroside H2
Hederoside H1
Glycoside L-H2
HEDERACOSIDE C
Ivy glycoside C
Hederacaucaside D
Akebia saponin pk
Astrantiasaponin H
Pulsatillasaponin F
total Ivy glycoside
kalopanax saponin B
KIZUTA SAPONIN K(12
Keywords ivy extract
Pulsatillasaponin II
Pericarpsasaponin Pk
HEDERACOSIDE C WITH HPLC
Hederacoside C 14216-03-6
4)-O-b-D-glucopyranosyl-(1®
Hederacoside C (Kalopanaxsaponin B)
6)-b-D-glucopyranosyl ester, (3b,4a)-
Hederacoside c, froM Hedera nepalensis
Hederacoside c, 98%, from Hedera nepalensis
3-O-α-L-Rhamnopyranosyl(1→2)-α-L-arabinopyranosylhederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl
Olean-12-en-28-oicacid, 3-[[2-O-(6-deoxy-a-L-Mannopyranosyl)-a-L-arabinopyranosyl]oxy]-23-hydroxy-, O-6-deoxy-a-L-Mannopyranosyl-(1®
3-[[2-O-(α-L-Rhamnopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid 6-O-[4-O-(α-L-rhamnopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester
(3beta,4alpha)-3-[[2-O-(6-Deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid O-6-deoxy-alpha-l-mannopyranosyl-(1->4)-O-beta-d-glucopyranosyl-(1->6)-beta-d-glucopyranosyl ester
Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl]oxy]-23-hydroxy-, O-6-deoxy-alpha-l-mannopyranosyl-(1->4)-O-beta-d-glucopyranosyl-(1->6)-beta-d-glucopyranosyl ester, (3beta,4alpha)-
Olean-12-en-28-oic acid, 3-[[2-o-(6-deoxy-.alpha.-L-mannopyranosyl)-.alpha.-L-arabinopyranosyl]oxy]-23-hydroxy-, o-6-deoxy-.alpha.-L-mannopyranosyl-(1.fwdarw.4)-o-.beta.-D-glucopyranosyl-(1.fwdarw.6)-.beta.-D-glucopyranosyl ester, (3.beta.,4.alpha.)- | [EINECS(EC#)]
238-072-2 | [Molecular Formula]
C59H96O26 | [MDL Number]
MFCD00198062 | [MOL File]
14216-03-6.mol | [Molecular Weight]
1221.38 |
| Chemical Properties | Back Directory | [Melting point ]
222 °C (dec.)(lit.)
| [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Sparingly) | [form ]
neat | [pka]
12.50±0.70(Predicted) | [color ]
White to Pale Beige | [BRN ]
4229541 | [Stability:]
Hygroscopic | [Major Application]
food and beverages | [InChIKey]
RYHDIBJJJRNDSX-MCGLQMIESA-N | [LogP]
4.520 (est) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
22-24/25 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [F ]
10-23 | [HS Code ]
29389090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
solubilizer, bio-availability enhancer in oral suspensions, capsules | [Definition]
ChEBI: A triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus. | [Synthesis]
Take dry manipulation ivy stems and leaves 500g, crushed, with 30% ethanol 4000mL, 2000mL at 80 ℃ successively heated reflux for two times, reflux time were 3 hours, 2 hours. Combine the two extracts, decompression recovery of solvent, get ivy crude extra | [in vivo]
Hederacoside C (0.625, 1.25, 2.5 mg/kg, intraperitoneally injected for 7 consecutive days) can alleviate TNBS-induced enteritis[1].
Hederacoside C (5, 10, 50 mg/kg, intraperitoneally injected for 3 consecutive times for 8 h) can attenuate the breast lesions caused by Staphylococcus aureus[2].
| Animal Model: | TNBS-induced colitis in rat[1] | | Dosage: | 0.625, 1.25, 2.5 mg/kg | | Administration: | i.p. for 7 days | | Result: | Decreased the levels of inflammatory cytokines, including TNF-α, IL-6, IL-1β, CXCL-1, CXCL-2, and CXCL-5.
Reduced cell apoptosis in TNBS-induced colitis.
Reduced Bax/Bcl-2 ratio, cleaved caspase 3, and p53 protein levels in a dose-dependent manner.
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