| Identification | Back Directory | [Name]
endo-BCN-PEG2-PFP ester | [CAS]
1421932-53-7 | [Synonyms]
endo-BCN-PEG2-PFP ester
4,7,12-Trioxa-10-azatridecanoic acid, 13-bicyclo[6.1.0]non-4-yn-9-yl-11-oxo-, 2,3,4,5,6-pentafluorophenyl ester | [Molecular Formula]
C24H26F5NO6 | [MDL Number]
MFCD28657159 | [MOL File]
1421932-53-7.mol | [Molecular Weight]
519.46 |
| Hazard Information | Back Directory | [Description]
endo-BCN-PEG2-PFP ester is a click chemistry active ester. The PFP esters have similar applications as the NHS esters, but are more stable in aqueous solution. They can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group can react with azide-tagged biomolecules. | [Uses]
endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG2-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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