1423058-85-8

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1423058-85-8 Structure

Identification	Back Directory
[Name] BRD9757
[CAS] 1423058-85-8
[Synonyms] BRD9757 BRD9757 (BRD 9757) BRD9757 >=98% (HPLC) N-Hydroxy-1-cyclopentene-1-carboxamide 1-Cyclopentene-1-carboxamide, N-hydroxy-
[Molecular Formula] C6H9NO2
[MDL Number] MFCD28118903
[MOL File] 1423058-85-8.mol
[Molecular Weight] 127.14

Chemical Properties	Back Directory
[density ] 1.257±0.06 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] H2O: soluble5mg/mL, clear (warmed)
[form ] powder
[pka] 9.30±0.23(Predicted)
[color ] white to beige
[Water Solubility ] H2O: 5mg/mL, clear (warmed)

Hazard Information	Back Directory
[Uses] BRD9757 is a potent and selective HDAC6 inhibitor (IC50 = 30 nM). Displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold).
[Definition] ChEBI: N-hydroxy-1-cyclopentenecarboxamide is an organic hydroxy compound.
[Biological Activity] Cell permeable: yes', 'Primary Target HDAC6', 'Reversible: yes
[IC 50] HDAC6: 0.03 μM (IC₅₀); HDAC1: 0.638 μM (IC₅₀); HDAC2: 1.79 μM (IC₅₀); HDAC3: 0.694 μM (IC₅₀); HDAC4: 21.80 μM (IC₅₀); HDAC5: 18.32 μM (IC₅₀); HDAC7: 12.61 μM (IC₅₀); HDAC8: 1.09 μM (IC₅₀); HDAC9: >33.33 μM (IC₅₀)
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] BRD9757(1423058-85-8)¹HNMR

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