| Identification | Back Directory | [Name]
FR 139317 | [CAS]
142375-60-8 | [Synonyms]
FR 139317
FR139317,CID107810
N,N-hexamethylenecarbamoyl-leu-N-*methyl-D-trp-D-
(N,N-HEXAMETHYLENE) CARBAMOYL-LEU-D-TRP(N-ME)-D-2-PYA
(HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-D-(1-ME)-TRP-DPAL
(HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-DTRP(ME)-D-ALA(2-PYRIDYL)-OH
D-Alanine, N-((hexahydro-1H-azepin-1-yl)carbonyl)-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-
N-[N-[N-[(HEXAHYDRO-1H-AZEPIN-1-YL)CARBONYL]-L-LEUCYL]-1-METHYL-D-TRYPTOPHYL]-3-(2-PYRIDINYL)-D-ALANINE
D-Alanine, N-(N-(N-((hexahydro-1H-azepin-1-yl)carbonyl)-L-leucyl)-1-methyl-D-tryptophyl)-3-(2-pyridinyl)-
2-((1-(Hexahydro-1H-azepinyl)carbonyl)amino-4-methylpentanoyl)-3-(-(1-methyl-1H-indolyl)propionyl)amino-3-(2-pyridyl)propionic acid
(2R)-2-[[(2R)-2-[[(2S)-2-(AZEPANE-1-CARBONYLAMINO)-4-METHYLPENTANOYL]AMINO]-3-(1-METHYLINDOL-3-YL)PROPANOYL]AMINO]-3-PYRIDIN-2-YLPROPANOIC ACID | [Molecular Formula]
C33H44N6O5 | [MDL Number]
MFCD00467722 | [MOL File]
142375-60-8.mol | [Molecular Weight]
604.74 |
| Chemical Properties | Back Directory | [Boiling point ]
943.9±65.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO | [form ]
Powder | [pka]
2.68±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
FR 139317 is a novel, potent endothelin ETA receptor antagonist. | [Biological Activity]
A highly potent and selective ET A endothelin receptor antagonist (K i values are 1 nM and 7.3 μ M at ET A and ET B subtypes respectively). Active in vivo . | [IC 50]
ETA | [storage]
Store at -20°C |
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