| Identification | Back Directory | [Name]
5-broMo-1-MethylpyriMidin-2-one | [CAS]
14248-01-2 | [Synonyms]
5-broMo-1-MethylpyriMidin-2-one
5-Bromo-1-methyl-2-pyrimidinone
5-Bromo-1-methylpyrimidin-2(1H)
5-Bromo-1-methyl-2(1H)-pyrimidinone
5‐bromo‐1‐methyl‐1,2‐dihydropyrimidin‐2‐one | [Molecular Formula]
C5H5BrN2O | [MDL Number]
MFCD11044136 | [MOL File]
14248-01-2.mol | [Molecular Weight]
189.01 |
| Chemical Properties | Back Directory | [Boiling point ]
215.9±50.0 °C(Predicted) | [density ]
1.73±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
0.31±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 1: Synthesis of 5-bromo-1-methylpyrimidin-2(1H)-one
A mixture of 5-bromopyrimidin-2(1H)-one (3 g), iodomethane (1.1 mL) and potassium carbonate (2.4 g) in N,N-dimethylformamide (60 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The residue was partitioned between water and dichloromethane. The organic phase was washed with brine, dried over anhydrous magnesium sulfate, and then concentrated to afford the target product 5-bromo-1-methylpyrimidin-2(1H)-one. Yield: 385 mg; liquid chromatography (Method 9): retention time t R = 0.25 min; mass spectrometry (ESI+): m/z = 189 [M + H]+. | [References]
[1] Patent: US2013/252937, 2013, A1. Location in patent: Paragraph 0767
[2] Patent: WO2013/144097, 2013, A1. Location in patent: Page/Page column 164
[3] Patent: WO2015/160636, 2015, A1. Location in patent: Page/Page column 155
[4] Patent: WO2015/160634, 2015, A1. Location in patent: Page/Page column 142 |
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