| Identification | Back Directory | [Name]
RWTWIZDKEIWLKQ-AXBPLXCXSA-N | [CAS]
1426174-16-4 | [Synonyms]
PubChem ID: 131667574
RWTWIZDKEIWLKQ-AXBPLXCXSA-N
Dextrorphan-d3 (tartrate) (CRM)
[2H3]- Dextrorphan Tartrate Salt | [Molecular Formula]
C21H29NO7 | [MOL File]
1426174-16-4.mol | [Molecular Weight]
407.46 |
| Hazard Information | Back Directory | [Description]
Dextrorphan-d3 (tartrate) (Item No. 15810) is intended for use as an internal standard for the quantification of dextrorphan (tartrate) (Item No. 15886) by GC- or LC-MS. Dextrorphan is categorized as an arylcyclohexylamine and is a metabolite of dextromethorphan (hydrobromide hydrate) (Item No. 13950), an antitussive found in cough medicines. Dextrorphan, while also having antitussive activity, is psychoactive, leading to the abuse of cough medicines containing the parent compound.1,2 Dextrorphan antagonizes NMDA and μ-opioid receptors (Kis = 54 and 420 nM, respectively) and inhibits norepinephrine and serotonin transporters (Kis = 340 and 401 nM, respectively).3,4,5 This product is intended for research and forensic applications. | [Uses]
A labelled Dextrorphan. Orally active synthetic morphine analog. Analgesic (narcotic). The labelled d-form of Levorphanol. | [References]
[1] YU-WEN CHEN. Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.[J]. Anesthesia and analgesia, 2007, 104 5: 1251-1255, tables of contents. DOI: 10.1213/01.ane.0000260330.18745.a8
[2] EUN-JOO SHIN . Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects[J]. Journal of pharmacological sciences, 2008, 106 1: Pages 22-27. DOI: 10.1254/jphs.fm0070177
[3] M DEMATTEIS M M G Lallement. Dextromethorphan and dextrorphan in rats: Common antitussives — Different behavioural profiles[J]. Fundamental & Clinical Pharmacology, 2009, 12 5: 526-537. DOI: 10.1111/j.1472-8206.1998.tb00982.x
[4] YUEH-CHING CHOU . Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan[J]. Brain Research, 1999, 821 2: Pages 516-519. DOI: 10.1016/s0006-8993(99)01125-7
[5] K L NICHOLSON R L B B A Hayes. Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys.[J]. Psychopharmacology, 1999, 146 1: 49-59. DOI: 10.1007/s002130051087 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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