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1428333-96-3

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1428333-96-3 Structure

1428333-96-3 Structure
IdentificationBack Directory
[Name]

BAY57-1293 mesylate
[CAS]

1428333-96-3
[Synonyms]

AIC316 mesylate
Pritelivir mesylate
BAY57-1293 mesylate
Pritelivir mesylate (BAY 57-1293)
[Molecular Formula]

C19H22N4O6S3
[MDL Number]

MFCD32671320
[MOL File]

1428333-96-3.mol
[Molecular Weight]

498.59
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 83.33 mg/mL (167.13 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.
[in vivo]

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].

Animal Model:Female BALB/c mice[3]
Dosage:0.03 to 45 mg/kg
Administration:Administered orally, twice daily at approximately 12 h intervals, for 7 days
Result:Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%.
[IC 50]

HSV-1: 0.02 μM (IC50); HSV-2: 0.02 μM (IC50)
Spectrum DetailBack Directory
[Spectrum Detail]

BAY57-1293 mesylate(1428333-96-3)1HNMR
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