| Identification | Back Directory | [Name]
M35 | [CAS]
142846-71-7 | [Synonyms]
M35
GWTLNSAGYLLGPPPGFSPFR-NH2
Galanin receptorligand M35
GALANIN (1-13)-BRADYKININ (2-9) AMIDE
Galanin (1-13)-Bradykinin (2-9), amide, M35
GALANIN FRAGMENT (1-13)-BRADYKININ*FRAGMENT (2-9)AM
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2
H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2
L-Argininamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl- | [Molecular Formula]
C107H153N27O26 | [MDL Number]
MFCD00237055 | [MOL File]
142846-71-7.mol | [Molecular Weight]
2233.52 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
solid
| [color ]
White to off-white | [Sequence]
Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2]. | [in vivo]
Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[1]. | [storage]
Store at -20°C | [References]
[1] Kask K, et al. Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59(3):341-8. DOI:10.1016/0167-0115(95)00089-t
[2] Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne). 2012 Dec 7;3:146. DOI:10.3389/fendo.2012.00146
[3] Ogren SO, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51(1):1-5. DOI:10.1016/0306-4522(92)90463-c |
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