| Identification | Back Directory | [Name]
PI4KIIIbeta-IN-9 | [CAS]
1429624-84-9 | [Synonyms]
PI4KIIIβ-IN-9
PI4KIIIbeta-IN-9
PI4KIIIbeta inhibitor 9
Cyclopentanecarboxamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]- | [Molecular Formula]
C23H25N3O5S2 | [MDL Number]
MFCD30187516 | [MOL File]
1429624-84-9.mol | [Molecular Weight]
487.59 |
| Chemical Properties | Back Directory | [density ]
1.421±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8?+-.0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. | [IC 50]
PI4KIIIβ: 7 nM (IC50); PI4KIIIα: 2.6 μM (IC50); PI3Kδ: 152 nM (IC50); PI3Kγ: 1046 nM (IC50); PI3Kα: 2 μM (IC50); PI3KC2γ: 1 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. DOI:10.1021/acs.jmedchem.5b01311 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|