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Sinitrodil (ITF 296) is an orally active organic nitrate with anti-ischaemic effect. Sinitrodil can be used for acute and chronic heart diseases research[1][2]. | [in vivo]
1.19 Pharmacokinetic parameters of Sinitrodil in rats[2]| Route | Parameter | Value | | IV (1 mg/kg) | CL (L/h/kg) | 2.7 | | AUC (μg h/mL) | 0.37 | | T1/2 (h) | 3.85 | | PO (5 mg/kg) | Tmax (h) | 0.17 | | T1/2 (h) | 1.95 | | Cmax (μg/mL) | 2.099 | | CL (L/h/kg) | 2.69 | | AUC (μg h/mL) | 1.364 |
| [References]
[1] Monzani MV, et al. Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. Eur J Pharm Sci. 1999 Feb;7(3):179-84. DOI:10.1016/s0928-0987(98)00026-8
[2] Monzani MV, et al. Pharmacokinetic Profile of ITF 296 in Rats and Dogs. Journal of Cardiovascular Pharmacology 26:p S67-71, |
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