| Identification | Back Directory | [Name]
CREB inhibitor (666-15) | [CAS]
1433286-70-4 | [Synonyms]
666-15
compound3i
CREB inhibitor
compound3i(666-15)
CREB inhibitor (666-15) | [Molecular Formula]
C33H31Cl2N3O5 | [MDL Number]
MFCD30182343 | [MOL File]
1433286-70-4.mol | [Molecular Weight]
620.53 |
| Hazard Information | Back Directory | [Uses]
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent. | [Biological Activity]
CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells. | [in vitro]
666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions. | [in vivo]
In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated. | [target]
| Target | Value | CREB
() | 81 nM |
| [storage]
Desiccate at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|