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VMY-2-95 is a selective desensitizer of α4β2 nicotinic acetylcholine receptors (nAChRs). | [Uses]
VMY-2-95 is an oral active and blood-brain barrier (BBB) penetrant α4β2 nicotinic acetylcholine receptor desensitizer. VMY-2-95 can be used for study of depression or addiction[1][2]. | [References]
[1] Kong H, et al. Preclinical studies of the potent and selective nicotinic α4β2 receptor ligand VMY-2-95. Mol Pharm. 2015;12(2):393-402. DOI:10.1021/mp5003569 [2] Yenugonda VM, et al. Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. J Med Chem. 2013;56(21):8404-8421. DOI:10.1021/jm4008455 |
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