| Identification | Back Directory | [Name]
ALX 40-4C | [CAS]
143413-49-4 | [Synonyms]
ALX 40-4C
D-Argininamide, N2-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI) | [Molecular Formula]
C56H113N37O10 | [MDL Number]
MFCD31630715 | [MOL File]
143413-49-4.mol | [Molecular Weight]
1464.74 |
| Hazard Information | Back Directory | [Uses]
ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. | [IC 50]
SDF-1-CXCR4: 1 μM (Ki); APJ receptor: 2.9 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. DOI:10.1089/08892220151126508
[2] Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. DOI:10.1016/s0166-3542(03)00071-8
[3] Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. DOI:10.1016/s0042-6822(03)00185-5 |
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| Company Name: |
Ontores Biotech
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| Tel: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
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