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1434517-02-8

1434517-02-8 Structure

1434517-02-8 Structure
IdentificationBack Directory
[Name]

Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)-
[CAS]

1434517-02-8
[Synonyms]

IMPDH2-IN-2
Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)-
[Molecular Formula]

C21H15Cl2N3O3
[MOL File]

1434517-02-8.mol
[Molecular Weight]

428.27
Chemical PropertiesBack Directory
[Boiling point ]

648.5±55.0 °C(Predicted)
[density ]

1.425±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

11.29±0.43(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].
[References]

[1] Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756. DOI:10.1021/acs.jmedchem.7b01839
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