Identification | Back Directory | [Name]
Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- | [CAS]
1434517-02-8 | [Synonyms]
IMPDH2-IN-2 Propanamide, 2-(2,3-dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-, (2S)- | [Molecular Formula]
C21H15Cl2N3O3 | [MOL File]
1434517-02-8.mol | [Molecular Weight]
428.27 |
Chemical Properties | Back Directory | [Boiling point ]
648.5±55.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.29±0.43(Predicted) | [color ]
Off-white to light yellow |
Hazard Information | Back Directory | [Uses]
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1]. | [References]
[1] Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756. DOI:10.1021/acs.jmedchem.7b01839 |
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