| Identification | Back Directory | [Name]
2,4-Difluoro-3-iodoaniline | [CAS]
1437316-91-0 | [Synonyms]
HE-CHEMICAL 0400806
2,4-Difluoro-3-iodoaniline
Benzenamine, 2,4-difluoro-3-iodo- | [Molecular Formula]
C6H4F2IN | [MOL File]
1437316-91-0.mol | [Molecular Weight]
255 |
| Chemical Properties | Back Directory | [Boiling point ]
266.7±40.0 °C(Predicted) | [density ]
2.086±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [pka]
2.30±0.10(Predicted) | [Appearance]
Off-white to light brown Solid |
| Hazard Information | Back Directory | [Uses]
2,?4-?Difluoro-?3-?iodoaniline is used in the synthetic preparation of purine derivatives that are protein kinase modulators useful in treatment and prevention of protein kinase-mediated diseases. | [Synthesis]
General procedure for the synthesis of 2,4-difluoro-3-iodoaniline from 1,3-difluoro-2-iodo-4-nitrobenzene: To a solution of concentrated hydrochloric acid (4 mL) of 1,3-difluoro-2-iodo-4-nitrobenzene (1.14 g, 4 mmol) was added anhydrous stannous chloride (2.71 g, 12 mmol), and the reaction mixture was heated to 50°C and kept for 1 hour. After completion of the reaction, the mixture was diluted with water, neutralized with 5% aqueous sodium hydroxide solution to pH=9, and then extracted with dichloromethane. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2,4-difluoro-3-iodoaniline (0.93 g, 91% yield).1H NMR (CDCl3): δ 6.70-6.93 (2H, m), 6.65 (2H, br). | [References]
[1] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0501-0503 |
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