| Identification | Back Directory | [Name]
NETROPSIN | [CAS]
1438-30-8 | [Synonyms]
f6
ia887
k-117
t1384
2814-a
ch-777-a
NCI 3067
NSC 3067
NETROPSIN
congocidin
antibiotic1142
ultrapuregrade
antibiotict-1384
NETROPSIN USP/EP/BP
1’-dimethyl-l)amino)-
Congocidin, Sinanomycin
NETROPSIN.2HCLRESEARCH GRADE
NETROPSIN ULTRA PURE GRADE 98+%
Netropsin dihydrochloride, dihydrate
Netropsin dihydrochloride,Congocidin, Sinanomycin
n,4’-bi(pyrrole-2-carboxamide),n’-(2-carbamoylethyl)-4-((2-guanidinoacetimidoy
4-[[2-[(Aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-1H-pyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl- | [EINECS(EC#)]
634-294-2 | [Molecular Formula]
C18H26N10O3 | [MDL Number]
MFCD01941622 | [MOL File]
1438-30-8.mol | [Molecular Weight]
430.46 |
| Chemical Properties | Back Directory | [Melting point ]
171-173℃ | [Boiling point ]
544.74°C (rough estimate) | [density ]
1.3374 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
−20°C
| [solubility ]
H2O: 1 mg/mL
| [form ]
powder
| [pka]
14.37±0.70(Predicted) | [color ]
faint yellow
| [EPA Substance Registry System]
Netropsin (1438-30-8) |
| Hazard Information | Back Directory | [Uses]
Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA. | [References]
[1] Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. DOI:10.1016/0167-4781(91)90036-l
[2] Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73(1): 341-343. |
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