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143851-98-3

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143851-98-3 Structure

143851-98-3 Structure
IdentificationBack Directory
[Name]

Elacridar HCl
[CAS]

143851-98-3
[Synonyms]

EOS-62093
Elacridar HC1
Elacridar HCl
Elacridar HCl USP/EP/BP
Elacridar (hydrochloride)
GF 120918A; GF120918A; GF-120918A
N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy
N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide monohydrochloride
GW 0918 N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide, (HCl salt)
4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)
1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid hydrochloride
[Molecular Formula]

C34H33N3O5.ClH
[MDL Number]

MFCD11040791
[MOL File]

143851-98-3.mol
[Molecular Weight]

600.112
Chemical PropertiesBack Directory
[Melting point ]

>198oC (dec.)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
[form ]

Solid
[color ]

Orange
[Stability:]

Hygroscopic
[CAS DataBase Reference]

143851-98-3
Hazard InformationBack Directory
[Chemical Properties]

yellow powder
[Uses]

Antineoplastic (adjunct).
[in vivo]

Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma[1].

1.19Plasma Pharmacokinetic Parameters of Elacridar hydrochloride in mice[1].
Mice
PO 100 mg/kg		Mice
IP 100 mg/kg		Mice
IV 2.5 mg/kg
CL/F (ml/min)2.0533.20.46
Vd/F (liter)3.512.30.17
t1/2 (h)204.34.4
AUC0-inf (μg·min/ml)146090.3161.4
F 0.220.0131
Animal Model:FVB wild-type mice[1]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 100 mg/kg once
Result:Showd a higher concertration in brain than plasma except at 4 h after administration.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Elacridar HCl(143851-98-3)1HNMR
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