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1438881-19-6

1438881-19-6 Structure

1438881-19-6 Structure
IdentificationBack Directory
[Name]

(2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyriMidin-4-yl]-1,2-propanediaMine
[CAS]

1438881-19-6
[Synonyms]

CRT0066854
CRT0066854 HCl
CRT-0066854 HCl
3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2S-propanediam
(S)-3-phenyl-N1-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propane-1,2-diamine
(2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyriMidin-4-yl]-1,2-propanediaMine
(2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine
1,2-Propanediamine, 3-phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-, (2S)-
[Molecular Formula]

C24H25N5S
[MDL Number]

MFCD28358788
[MOL File]

1438881-19-6.mol
[Molecular Weight]

415.55
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 30 mg/ml
[form ]

A crystalline solid
[color ]

White to yellow
Hazard InformationBack Directory
[Description]

CRT0066854 is an inhibitor of PKCι and PKCζ (IC50s = 132 and 639 nM, respectively). It also inhibits the Rho-associated kinase II (ROCK2) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK2 over typical PKCs and 98 other kinases in a panel at 1 μM. CRT0066854 decreases phosphorylation of the atypical PKC substrate lethal giant larvae 2 (LLGL2) in HEK293 cells expressing PKCι and LLGL2. It decreases viability of A549 lung carcinoma cells (IC50 = 3.47 μM) and decreases colony formation in HeLa cells by 65% when used at a concentration of 1 μM. CRT0066854 impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay.
[Uses]

(2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine, is used in the synthesis of synthesis of Alpha protein kinase C (PKC) inhibitor.
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